Doctor Octopus (Otto Octavius)
After the explosion that grafted the tentacled harness to Dr. Octavius, he was misdiagnosed with brain damage. In actuality, his brain was creating new neuro-pathways so that he could possess the superhuman ability to telepathically control his tentacles at will.
Originally, at his earliest stages, it was thought he could only control his tentacles while they were attached to him. However, when he became separated from his tentacles, he proved he was able to telepathically control them, even if they were a considerable distance. More on Marvel.com